The role of integration in oncogenic progression of HPV-associated cancers

AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …

Epigenetic regulation of human papillomavirus transcription in the productive virus life cycle

M Burley, S Roberts, JL Parish - Seminars in immunopathology, 2020 - Springer
Human papillomaviruses (HPV) are a large family of viruses which contain a circular, double-
stranded DNA genome of approximately 8000 base pairs. The viral DNA is chromatinized by …

Oncogenic human papillomaviruses

AA McBride - … Transactions of the Royal Society B …, 2017 - royalsocietypublishing.org
Human papillomaviruses (HPVs) are an ancient group of viruses with small, double-
stranded DNA circular genomes. They are species-specific and have a strict tropism for …

[HTML][HTML] Human papillomaviruses in epigenetic regulations

J Durzynska, K Lesniewicz, E Poreba - Mutation Research/Reviews in …, 2017 - Elsevier
Abstract Human Papillomaviruses (HPVs) are double-stranded DNA viruses, that infect
epithelial cells and are etiologically involved in the development of human cancer. Today …

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

A Gagliardi, VL Porter, Z Zong, R Bowlby, E Titmuss… - Nature …, 2020 - nature.com
Cervical cancer is the most common cancer affecting sub-Saharan African women and is
prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer …

Epigenetic regulation of the human papillomavirus life cycle

M Mac, CA Moody - Pathogens, 2020 - mdpi.com
Persistent infection with certain types of human papillomaviruses (HPVs), termed high risk,
presents a public health burden due to their association with multiple human cancers …

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

I Pentland, K Campos-León, M Cotic, KJ Davies… - PLoS …, 2018 - journals.plos.org
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated
basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted …

Cellular redox, cancer and human papillomavirus

A Cruz-Gregorio, J Manzo-Merino, M Lizano - Virus Research, 2018 - Elsevier
Abstract High-risk Human Papillomavirus (HR-HPV) is the causative agent of different
human cancers. A persistent HR-HPV infection alters several cellular processes involved in …

Tandemly integrated HPV16 can form a Brd4-dependent super-enhancer-like element that drives transcription of viral oncogenes

KE Dooley, A Warburton, AA McBride - MBio, 2016 - Am Soc Microbiol
In cancer cells associated with human papillomavirus (HPV) infections, the viral genome is
very often found integrated into the cellular genome. The viral oncogenes E6 and E7 are …

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

IJ Groves, N Coleman - The Journal of pathology, 2018 - Wiley Online Library
Human papillomavirus (HPV) infection is associated with∼ 5% of all human cancers,
including a range of squamous cell carcinomas. Persistent infection by high‐risk HPVs …