The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

[HTML][HTML] A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications

DD Huang, G Shi, Y Jiang, C Yao, C Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Diabetes mellitus (DM) is a major world health problem and one of the most studied
diseases, which are highly prevalent in the whole world, it is frequently associated with …

An overview of herbal products and secondary metabolites used for management of type two diabetes

A Ota, NP Ulrih - Frontiers in pharmacology, 2017 - frontiersin.org
Diabetes mellitus is a common effect of uncontrolled high blood sugar and it is associated
with long-term damage, dysfunction, and failure of various organs. In the adult population …

[HTML][HTML] Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

JA McCubrey, K Lertpiriyapong, LS Steelman… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and
other health-enhancing effects. A key target of the effects of natural products may be the …

SIRT1-FOXOs activity regulates diabetic complications

MP Jalgaonkar, UM Parmar, YA Kulkarni… - Pharmacological …, 2022 - Elsevier
The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

Sirtuins, resveratrol and the intertwining cellular pathways connecting them

A Ungurianu, A Zanfirescu, D Margină - Ageing Research Reviews, 2023 - Elsevier
Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

The aging heart

V Obas, RS Vasan - Clinical Science, 2018 - portlandpress.com
As the elderly segment of the world population increases, it is critical to understand the
changes in cardiac structure and function during the normal aging process. In this review …

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

MR Ramis, S Esteban, A Miralles, DX Tan… - Mechanisms of ageing …, 2015 - Elsevier
Aging is an inevitable and multifactorial biological process. Free radicals have been
implicated in aging processes; it is hypothesized that they cause cumulative oxidative …

Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action

V Dutt, S Gupta, R Dabur, E Injeti, A Mittal - Pharmacological Research, 2015 - Elsevier
Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy
under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic …

Cardiomyocytes cellular phenotypes after myocardial infarction

AM Lodrini, MJ Goumans - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Despite the increasing success of interventional coronary reperfusion strategies, mortality
related to acute myocardial infarction (MI) is still substantial. MI is defined as sudden death …