Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin
and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 …

Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …

Sequence analysis revealed phospholipase A 2 (PLA 2) motifs in capsid proteins of
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …

Decapentaplegic (Dpp), a Drosophila TGFβ/bone morphogenetic protein homolog, functions
as a morphogen to specify cell fate along the anteroposterior axis of the wing. Dpp is a …

Growth factor activity is localized within the natural extracellular matrix (ECM) by specific
noncovalent interactions with core ECM biomolecules, such as proteins and proteoglycans …

Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans
from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells …

We examined cytoplasmic trafficking and nuclear translocation of adeno-associated virus
type 2 (AAV) by using Alexa Fluor 488-conjugated wild-type AAV, A20 monoclonal antibody …

An emerging body of evidence suggests that type IIA secretory phospholipase A 2 (sPLA 2-
IIA) participates in the amplification of the stimulus-induced cyclooxygenase (COX)-2 …

Although adeno-associated virus type 2 (AAV) has gained attention as a potentially useful
alternative to the more commonly used retrovirus-and adenovirus-based vectors for human …

Cell surface heparan sulfate (HS) not only binds several major classes of growth factors but
also sometimes potentiates their activities—an effect usually termed “coreception.” A view …