1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Organic synthesis is one of the most successful and useful disciplines of science and mainly
involves the construction of carbon-carbon bond (s) and carbon-heteroatom bond (s) and …

Acquiring the capability to access structurally complex and diverse molecules through
simple starting substrates has been one of the underlying principles of chemical research …

Oxindoles are structural motifs that are widely present in natural products and medicinally
important agents.[1] In particular, spirocyclic oxindoles bearing a quaternary stereogenic …

Spirocyclopropyl oxindoles are widely present in natural products and bioactive molecules.
In addition, they play a significant role as a type of donor–acceptor (DA) cyclopropanes in …

Synthesis of Novel Functionalized 3-Spiropyrrolizidine and 3-Spiropyrrolidine Oxindoles
from Baylis−Hillman Adducts of Isatin and Heteroaldehydes with Azomethine Ylides via [3+2]-Cycloaddition …

Because of their definite or potential biological and pharmaceutical activities, spirooxindole
heterocycles have been widely studied, and there has occurred a research boom on routes …

The first tertiary amine catalyzed enantioselective Morita− Baylis− Hillman (MBH) reaction of
isatins with acrylates has been demonstrated, allowing asymmetric synthesis of biologically …

Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino
Michael/intramolecular nucleophilic substitution pathway with variously substituted vinyl …

An activation of the pyridine nucleus has been achieved via 1, 5-electrocyclization of vinyl
pyridinium ylides generated from bromo isomerized Morita− Baylis− Hillman adducts of …