Abortive infection: bacterial suicide as an antiviral immune strategy
Facing frequent phage challenges, bacteria have evolved numerous mechanisms to resist
phage infection. A commonly used phage resistance strategy is abortive infection (Abi), in …
phage infection. A commonly used phage resistance strategy is abortive infection (Abi), in …
History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology
Y Ishino, M Krupovic, P Forterre - Journal of bacteriology, 2018 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
RNA-targeting CRISPR–Cas systems
SPB van Beljouw, J Sanders… - Nature Reviews …, 2023 - nature.com
CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …
protects against viral infection by targeting specific invading nucleic acid sequences …
A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems
Type III CRISPR-Cas systems in prokaryotes provide immunity against invading nucleic
acids through the coordinated degradation of transcriptionally active DNA and its transcripts …
acids through the coordinated degradation of transcriptionally active DNA and its transcripts …
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
O Niewoehner, C Garcia-Doval, JT Rostøl, C Berk… - Nature, 2017 - nature.com
In many prokaryotes, type III clustered regularly interspaced short palindromic repeat
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …
Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex
K Kato, W Zhou, S Okazaki, Y Isayama, T Nishizawa… - Cell, 2022 - cell.com
Summary The type III-E CRISPR-Cas effector Cas7-11, with dual RNase activities for
precursor CRISPR RNA (pre-crRNA) processing and crRNA-guided target RNA cleavage, is …
precursor CRISPR RNA (pre-crRNA) processing and crRNA-guided target RNA cleavage, is …
Cyclic nucleotide signaling in phage defense and counter-defense
JS Athukoralage, MF White - Annual review of virology, 2022 - annualreviews.org
Advances in our understanding of prokaryotic antiphage defense mechanisms in the past
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
[HTML][HTML] Antiviral type III CRISPR signalling via conjugation of ATP and SAM
CRISPR systems are widespread in the prokaryotic world, providing adaptive immunity
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
against mobile genetic elements,. Type III CRISPR systems, with the signature gene cas10 …
The revolution continues: newly discovered systems expand the CRISPR-Cas toolkit
CRISPR-Cas systems defend prokaryotes against bacteriophages and mobile genetic
elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 …
elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 …