The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

NF-kappa B is a ubiquitous transcription factor. Nevertheless, its properties seem to be most
extensively exploited in cells of the immune system. Among these properties are NF-kappa …

Explaining the genetics of many diseases is challenging because most associations localize
to incompletely characterized regulatory regions. Using new computational methods, we …

Virus infections induce a proinflammatory response including expression of cytokines and
chemokines. The subsequent leukocyte recruitment and antiviral effector functions …

Abstract The Epstein–Barr virus (EBV)-encoded latent membrane protein-1 (LMP1), a
functional homologue of the tumor necrosis factor receptor family, substantially contributes to …

Human immunodeficiency virus 1 (HIV1) infection is associated with severe psoriasis, B cell
lymphoma, and Kaposi's sarcoma. A deregulated production of interleukin 6 (IL-6) has been …

Publisher Summary This chapter focuses on the REL/NF-κB/IKB story. NF-κB is a
transcription factor first identified as a lymphoid-specific protein that binds to a decameric …

Human immunodeficiency virus type 1 (HIV-1) infection is associated with severe psoriasis,
B cell lymphoma, and Kaposi's sarcoma. A deregulated production of interleukin-6 (IL6) has …

Viral load is an important marker of activity of viral diseases for a number of viruses. We
wished to evaluate whether the viral load of human herpesvirus 8 (HHV-8) in peripheral …

Functional retroviral integrase protein is thought to be essential for productive viral
replication. Yet, previous studies differed on the extent to which integrase mutant viruses …