Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Cisplatin (CP) is a widely used chemotherapeutic drug, effective against a variety of solid
tumours, though its utility is limited due to its multiple organ toxicity. Zingerone (ZO), one of …

BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

The aim of this study is to examine the protective effect of naringenin‐oxime (NOX) on
cisplatin‐induced major organ toxicity and DNA damage in rats. Thirty‐five male Wistar …

The off‐target testicular toxicity of the anticancer drug, cisplatin, is a current clinical concern
and worrisome to male cancer patients. Growing evidence has implicated oxidative stress …

Cyclophosphamide (CP) causes infertility due to ovarian toxicity. The toxicity mechanism
suggests oxidative stress. We assessed whether mirtazapine (MTZ) and hesperidin (HSP) …

Mirtazapine (MTZ) is an antidepressant drug with an exceptional pharmacological profile. It
also has an excellent safety and tolerability profile. The present review provides a …

Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is
still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of …

Simple Summary Tumor cells are highly resistant to oxidative stress, but beyond a certain
threshold, it may lead to apoptosis/necrosis. Thus, induced loss of redox balance can be a …