Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

This review discusses recent advances in the chemistry of saturated boronic acids,
boronates, and trifluoroborates. Applications of the title compounds in the design of boron …

The design of molecular catalysts typically involves reconciling multiple conflicting property
requirements, largely relying on human intuition and local structural searches. However, the …

Fully automated synthetic chemistry would substantially change the field by providing broad
on-demand access to small molecules. However, the reactions that can be run …

The development of an enantioselective catalytic Suzuki–Miyaura reaction that applies to
meso 1, 2-diborylcycloalkanes is described. This reaction provides a modular route to …

Copper-catalyzed stereospecific cross-couplings of boronic esters are reported. Boron “ate”
complexes derived from pinacol boronic esters and tert-butyl lithium undergo stereospecific …

The diastereo‐and enantioselective diboration of spirocyclobutenes provides a platform for
the rapid preparation of a wide variety of chiral spirocyclic building blocks. The …

Advances in Pd-catalysed cross-coupling reactions have facilitated the development of
stereospecific variants enabling the use of configurationally stable, enantioenriched, main …

A novel strategy for the stereospecific Pd-catalyzed acylative cross-coupling of
enantiomerically enriched alkylboron compounds has been developed. The protocol …

Catalytic transformations involving Pd (0)/Pd (II) catalytic cycles are very well known, and
processes involving high-valent Pd (III) and Pd (IV) and low-valent Pd (I) intermediates have …