Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics
and is characterized by pain and limitation of joint function. Due to the difficulty of …

Background Although mesenchymal stem cells (MSCs) have been effective in tendinopathy,
the mechanisms by which MSCs promote tendon healing have not been fully elucidated. In …

Tendon stem/progenitor cells (TSPCs) therapy is a promising strategy for enhancing cell
matrix and collagen synthesis, and regulating the metabolism of the tendon …

Macrophages are involved mainly in the balance between inflammation and tenogenesis
during the healing process of tendinopathy. However, etiological therapeutic strategies to …

Objective Tissue crosstalk mediated by secreted hormones underlies the integrative control
of metabolism. We previously showed that CTRP13/C1QL3, a secreted protein of the C1q …

Tendinopathy is a common disease in orthopaedics, seriously affecting tendon functions.
However, the effects of non-surgical treatment on tendinopathy are not satisfactory and …

Background Tendinopathy is the leading sports-related injury and will cause severe
weakness and tenderness. Effective therapy for tendinopathy remains limited, and …

While hypoxic signaling has been shown to play a role in many cellular processes, its role in
metabolism-linked extracellular matrix (ECM) organization and downstream processes of …

Background Currently, there are no specific drugs or targets available for the treatment of
tendinopathy. However, inflammation has recently been found to play a pivotal role in …