Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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CRISPR/Cas systems for genomic modification and gene modulation
F Wu - US Patent 9,738,908, 2017 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification and
regulation of gene expression in mammalian cells. The specification describes the design …
regulation of gene expression in mammalian cells. The specification describes the design …
CRISPR-based genome modification and regulation
F Chen, GD Davis - US Patent 10,731,181, 2020 - Google Patents
The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
Methods and compositions for the targeted modification of a mouse genome
D Frendewey, W Auerbach, KV Lai… - US Patent …, 2017 - Google Patents
Compositions and methods are provided for modifying a genomic locus of interest in a
eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a …
eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
JK Joung, JD Sander, M Maeder, Y Fu - US Patent 9,567,604, 2017 - Google Patents
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Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
JK Joung, S Tsai - US Patent 9,567,603, 2017 - Google Patents
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CRISPR-related methods and compositions with governing gRNAS
F Zhang, D Palestrant, B Davidson, J Mata-Fink… - US Patent …, 2017 - Google Patents
US9834791B2 - CRISPR-related methods and compositions with governing gRNAS -
Google Patents US9834791B2 - CRISPR-related methods and compositions with …
Google Patents US9834791B2 - CRISPR-related methods and compositions with …
Compositions and methods directed to CRISPR/Cas genomic engineering systems
F Wu - US Patent 9,234,213, 2016 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification in
mammalian cells. The present specification describes the design and testing of a polynucle …
mammalian cells. The present specification describes the design and testing of a polynucle …
Increasing specificity for RNA-guided genome editing
JK Joung, J Angstman, JD Sander, M Maeder… - US Patent …, 2018 - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …