The past decade has seen fundamental advances in our understanding of the ageing
process and raised optimism that interventions to slow ageing may be on the horizon …

The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life
span (CLS) and the replicative life span (RLS). The chronological life span is a measure of …

Insight on the underlying mechanisms of aging will advance our ability to extend healthspan,
treat age-related pathology and improve quality of life. Multiple genetic and pharmacological …

Cells survey their environment and need to balance growth and anabolism with stress
programmes and catabolism towards maximum cellular bioenergetics economy and …

Either calorie restriction, loss‐of‐function of the nutrient‐dependent PKA or TOR/SCH9
pathways, or activation of stress defences improves longevity in different eukaryotes …

Mitochondrial involvement in yeast apoptosis is probably the most unifying feature in the
field. Reports proposing a role for mitochondria in yeast apoptosis present evidence ranging …

Saccharomyces cerevisiae is the simplest among the major eukaryotic model organisms for
aging and diseases. Longevity in the chronological life span paradigm is measured as the …

Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes,
and metazoans. However, excess of glucose has been associated with several diseases …

The fission yeast Schizosaccharomyces pombe is an excellent model for cellular
quiescence that can be achieved experimentally with nutritional limitations. The target of …

The multi-subunit eukaryotic translation initiation factor eIF3 is thought to assist in the
recruitment of ribosomes to mRNA. The expression of eIF3 subunits is frequently disrupted …