Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …

Chronic rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal and paranasal
sinus mucosa that affects up to 10% of the population worldwide. CRS is the most …

Chronic colonic inflammation is a feature of cancer and is strongly associated with
tumorigenesis, but its underlying molecular mechanisms remain poorly understood …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of
the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) is involved in …

Background Epithelial remodeling is a prominent feature of eosinophilic chronic
rhinosinusitis with nasal polyps (eCRSwNP), and infiltration of M2 macrophages plays a …

Background Diesel exhaust particles (DEPs) are associated with the prevalence and
exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma …

The human sirtuins (SIRT1–SIRT7) enzymes are a highly conserved family of NAD+‐
dependent histone deacetylases, which play a critical role in the regulation of a large …

The respiratory epithelium of the upper airways is a first‐line defence against inhaled
irritants, pathogens and allergens. It ensures a physical barrier provided by apical junctions …

Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease
characterized by involvement of diverse types of inflammatory cells. Asian CRS patients …

In the present study, we examined the potential of cell-penetrating peptide (CPP)-based
intranasal drug delivery for the treatment of localized nasal diseases. Many charged or non …