The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in
pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also …

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …

The habenula has been implicated in the pathogenesis of pain and analgesia, while
evidence concerning its function in chronic low back pain (cLBP) is sparse. This study aims …

Persistent ocular pain caused by corneal inflammation and/or nerve injury is accompanied
by significant alterations along the pain axis. Both primary sensory neurons in the trigeminal …

The lateral habenula (LHb) and the ventral tegmental area (VTA), which form interconnected
circuits, have important roles in the crucial control of sensory and cognitive motifs. Signaling …

Background The precise underlying mechanisms of migraine remain unknown. Although we
have previously shown acute orofacial pain evoked changes within the brainstem of …

Hyperalgesia often occurs in alcoholics, especially during abstinence, yet the underlying
mechanisms remain elusive. The lateral habenula (LHb) has been implicated in the …

Irritable bowel syndrome (IBS) is a disorder involving dysfunctional brain–gut interactions
characterized by chronic recurrent abdominal pain, altered bowel habits, and negative …

Aims Comorbid anxiodepressive‐like symptoms (CADS) in chronic pain are closely related
to the overactivation of the lateral habenula (LHb). Hyperpolarization‐activated cyclic …

The altered activity generated by corneal neuronal injury can result in morphological and
physiological changes in the architecture of synaptic connections in the nervous system …