Artemisinin-derived hybrids and their anticancer activity
F Gao, Z Sun, F Kong, J Xiao - European journal of medicinal chemistry, 2020 - Elsevier
The emergence of drug-resistance and the low specificity of anticancer agents are the major
challenges in the treatment of cancer and can result in many side effects, creating an urgent …
challenges in the treatment of cancer and can result in many side effects, creating an urgent …
2‐Isoxazolines: A synthetic and medicinal overview
Isoxazolines are nitrogen‐and oxygen‐containing five‐membered heterocyclic scaffolds
with extensive biological activities. This framework can be readily obtained in good to …
with extensive biological activities. This framework can be readily obtained in good to …
[HTML][HTML] Isoxazole/Isoxazoline skeleton in the structural modification of natural products: a review
X Wang, Q Hu, H Tang, X Pan - Pharmaceuticals, 2023 - mdpi.com
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
[HTML][HTML] Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene) penicillanate: batch, microwave-induced and continuous flow …
AJS Alves, JAD Silvestre, TMVDP e Melo - RSC advances, 2022 - pubs.rsc.org
The first examples of the diastereoselective 1, 3-dipolar cycloaddition reaction of nitrile
oxides and 6-alkylidene penicillanates leading to chiral spiroisoxazoline-penicillanates are …
oxides and 6-alkylidene penicillanates leading to chiral spiroisoxazoline-penicillanates are …
A DFT study of the double (3+ 2) cycloaddition of nitrile oxides and allenoates for the formation of spirobiisoxazolines
The molecular mechanism of the double (3+ 2) cycloaddition (32CA) reaction between nitrile
oxides and allenoates has been studied using density functional theory at the M06-2X/6 …
oxides and allenoates has been studied using density functional theory at the M06-2X/6 …
Theoretical analysis of the regio-and stereoselective synthesis of spiroisoxazolines
N Acharjee - Journal of Molecular Modeling, 2020 - Springer
Abstract The [3+ 2] cycloaddition (32CA) reaction of benzonitrile oxide to α-methylene
cyclopentanone and propionitrile oxide to γ-methyl-α-methylene-γ-butyrolactone, yielding …
cyclopentanone and propionitrile oxide to γ-methyl-α-methylene-γ-butyrolactone, yielding …
[PDF][PDF] Synthesis of new spiroheterocycles-fused isoxazoline from 2-arylidenes-3-phenyl-1-indanones through a regio-and diastereospecific 1, 3-dipolar cycloaddition
M Bakhouch, Y Kanzouai, R Bouzammit… - … Journal of Chemistry, 2021 - academia.edu
New spiroisoxazolines 3 have been synthesized by 1, 3-dipolar cycloaddition of arylnitrile
oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and …
oxides with 2-arylidenes-3-phenyl-1-indanones. The reaction occurs in a regiospecific and …