Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop
contractile weakness of the diaphragm. Consequently, they may experience difficulty …

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere,
responsible for passive force development at sarcomere length (SL) above the physiological …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …

BACKGROUND: Lower extremity peripheral artery disease (PAD) is a growing epidemic
with limited effective treatment options. Here, we provide a single-nuclei atlas of PAD limb …

Abstract Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the
muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …