Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

The microcirculation is highly responsive to, and a vital participant in, the inflammatory
response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit …

Background—Although lymphocyte recruitment and activation are associated with cerebral
ischemia-reperfusion (I/R) injury, the contributions of specific lymphocyte subpopulations …

T cells contribute to the pathophysiology of ischemic stroke by yet unknown mechanisms.
Mice with transgenic T-cell receptors (TCRs) and mutations in costimulatory molecules were …

Leukocytes have been implicated in the pathogenesis of ischemic acute renal failure (ARF),
but the roles of the individual cell types involved are largely unknown. Recent indirect …

Abstract A 2A adenosine receptor (A 2A R)-expressing bone marrow (BM)-derived cells
contribute to the renal protective effect of A 2A agonists in renal ischemia-reperfusion injury …

The pathogenesis of ischemia–reperfusion injury (IRI) is complex and not well understood.
Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion …

The T cell as a bridge between innate and adaptive immune systems: Implications for the
kidney. The immune system is classically divided into innate and adaptive components with …

Stroke induces a complex web of pathophysiology that may evolve over hours to days and
weeks after onset. It is now recognized that inflammation is an important phenomenon that …

Recent data support a modulatory role for CD4 T cells in experimental renal ischemia-
reperfusion injury (IRI). CD4 T cells can functionally differentiate to either a Th1 (IFN-γ …