Healthy effects of plant polyphenols: molecular mechanisms

M Leri, M Scuto, ML Ontario, V Calabrese… - International journal of …, 2020 - mdpi.com
The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

Natural polyphenols for prevention and treatment of cancer

Y Zhou, J Zheng, Y Li, DP Xu, S Li, YM Chen, HB Li - Nutrients, 2016 - mdpi.com
There is much epidemiological evidence that a diet rich in fruits and vegetables could lower
the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Resveratrol as an anti-cancer agent: A review

A Rauf, M Imran, MS Butt, M Nadeem… - Critical reviews in …, 2018 - Taylor & Francis
Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera
L.) are the archetypal paradigms of fruits used not only for nutritional purposes, but also for …

Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Resveratrol inhibited the metastatic behaviors of cisplatin‐resistant human oral cancer cells via phosphorylation of ERK/p‐38 and suppression of MMP‐2/9

WS Chang, CW Tsai, JS Yang, YM Hsu… - Journal of Food …, 2021 - Wiley Online Library
Cisplatin resistance is a major clinical problem in the clinical management of oral squamous
cell carcinoma (OSCC) patients. Resveratrol is a natural phytoestrogen with antitumor …

Recent advances in metal‐phenolic networks for cancer theranostics

Z Zhang, L Xie, Y Ju, Y Dai - Small, 2021 - Wiley Online Library
Nanomedicine integrates different functional materials to realize the customization of
carriers, aiming at increasing the cancer therapeutic efficacy and reducing the off‐target …

The regulation of autophagy by calcium signals: Do we have a consensus?

MD Bootman, T Chehab, G Bultynck, JB Parys… - Cell calcium, 2018 - Elsevier
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy

I Arora, M Sharma, TO Tollefsbol - International journal of molecular …, 2019 - mdpi.com
Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …