Abstract Machine learning models may be integrated into clinical decision support (CDS)
systems to identify children at risk of specific diagnoses or clinical deterioration to provide …

Background Efforts to develop an evidence-based approach to the evaluation and
management of young febrile infants have spanned more than 4 decades. 1 In the 1970s …

Sepsis, defined as an infection with dysregulated host response leading to life‐threatening
organ dysfunction, continues to carry a high potential for morbidity and mortality in children …

Objectives Identifying infection aetiology is essential for appropriate antibiotic use. Previous
studies have shown that a host-protein signature consisting of TNF-related apoptosis …

Background In children with urinary tract infection (UTI), only those with pyelonephritis (and
not cystitis) are at risk for developing long‐term renal sequelae. If non‐invasive biomarkers …

Importance Febrile infants at low risk of invasive bacterial infections are unlikely to benefit
from lumbar puncture, antibiotics, or hospitalization, yet these are commonly performed. It is …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated response of the host
to infection. It represents one of the major health care problems worldwide. Unfortunately …

Sepsis remains a significant cause of neonatal morbidity and mortality in China. A better
understanding of neonatal sepsis in China as compared with other industrialized and non …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Antimicrobial resistance (AMR) is a growing global concern in infectious disease
management, leading to increased morbidity and mortality rates, and having a greater …