Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis

M Tan, Y Yin, X Ma, J Zhang, W Pan, M Tan… - Cell Death & …, 2023 - nature.com
The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Diet, lifestyle and cardiovascular diseases: linking pathophysiology to cardioprotective effects of natural bioactive compounds

J Sharifi-Rad, CF Rodrigues, F Sharopov… - International journal of …, 2020 - mdpi.com
Heart and blood vessels disorders comprise one of the main causes of death worldwide.
Pharmacologically active natural compounds have been used as a complementary therapy …

Green Biosynthesized Silver Nanoparticles With Aqueous Extracts of Ginkgo Biloba Induce Apoptosis via Mitochondrial Pathway in Cervical Cancer Cells

Z Xu, Q Feng, M Wang, H Zhao, Y Lin, S Zhou - Frontiers in oncology, 2020 - frontiersin.org
Biosynthetic silver nanoparticles (AgNPs), specifically formed using medicinal plant extracts,
have recently exhibited a remarkable therapeutic effect due to their anticancer potential …

Mitochondrial Modulators: the defender

E Makinde, L Ma, GD Mellick, Y Feng - Biomolecules, 2023 - mdpi.com
Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

Red blood cell distribution width to platelet ratio predicts early neurological deterioration in acute ischemic stroke patients receiving intravenous thrombolysis

M Jiang, J Shen, B Muhammad, D Geng - Journal of Stroke and …, 2023 - Elsevier
Background Inflammation plays a prominent role in the pathogenesis and progression of
acute ischemic stroke (AIS). The red blood cell distribution width to platelet ratio (RPR) has …

Fasting blood glucose as a predictor of progressive infarction in men with acute ischemic stroke

Q Yu, X Mao, Z Fu, S Luo, Q Huang… - Journal of …, 2022 - journals.sagepub.com
Objective Blood glucose is related to early neurological deterioration in acute ischemic
stroke, but multiple mechanisms are involved in early neurological deterioration, such as …

[HTML][HTML] Cinnamic acid mitigates left ventricular hypertrophy and heart failure in part through modulating FTO-dependent N6-methyladenosine RNA modification in …

Y Cui, P Wang, M Li, Y Wang, X Tang, J Cui… - Biomedicine & …, 2023 - Elsevier
Left ventricular hypertrophy leads to heart failure, a serious medical condition associated
with high rates of hospitalization and mortality. Limited success with the existing …

Admission glucose levels may increase the risk for early neurological deterioration in females with acute ischemic stroke

ZX Huang, Y Huang, J Zeng, H Hao… - Frontiers in …, 2020 - frontiersin.org
Background and purpose: Early neurological deterioration (END) is associated with poor
outcome for patients with acute ischemic stroke (AIS). Patients with hyperglycemia have …

Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation

CR Sruthi, KG Raghu - Journal of cellular biochemistry, 2022 - Wiley Online Library
Methylglyoxal (MGO) is a toxic, highly reactive metabolite derived mainly from glucose and
amino acids degradation. MGO is also one of the prime precursors for advanced glycation …

[HTML][HTML] Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010

QR Lin, LQ Jia, M Lei, D Gao, N Zhang, L Sha… - Pharmacological …, 2024 - Elsevier
Diabetes, characterized as a well-known chronic metabolic syndrome, with its associated
complications pose a substantial and escalating health and healthcare challenge on a …