Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Background Neuronal networks in the brain include glutamatergic principal neurons and
GABAergic interneurons (GABA, γ-aminobutyric acid). The latter may be a minority cell type …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

A wealth of data has elucidated the mechanisms by which sensory inputs are encoded in the
neocortex, but how these processes are regulated by the behavioral relevance of sensory …

Neuronal networks consist of different types of neurons that all play their own role in order to
maintain proper network function. The two main types of neurons segregate in excitatory and …

Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …

The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …