Chronic urticaria is defined as the presence of urticaria for a period exceeding 6 weeks,
assuming symptoms for most days of the week. It is divided into chronic inducible urticarias …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Abstract Background Familial Mediterranean fever, mevalonate kinase deficiency (also
known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor …

During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …

Periodic fever syndromes are autoinflammatory diseases. The majority present in infancy or
childhood and are characterised by recurrent episodes of fever and systemic inflammation …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Monogenic autoinflammatory diseases are rare conditions caused by genetic abnormalities
affecting the innate immunity. Previous therapeutic strategies had been mainly based on …

Mevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder
characterized by life-long recurring episodes of fever and inflammation, often without clear …

Systemic autoinflammatory diseases are a heterogeneous family of disorders characterized
by a dysregulation of the innate immune system, in which sterile inflammation primarily …

Autoinflammatory diseases (AIDs) are heterogeneous disorders characterized by
dysregulation in the inflammasome, a large intracellular multiprotein platform, leading to …