Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

There is an alarming global increase in the incidence of end-stage kidney disease, for which
early biomarkers and effective treatment options are lacking. Largely based on the histology …

High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Every optical imaging technique is limited in its penetration depth by scattering occurring in
biological tissues. Possible solutions to overcome this problem consist of limiting the …

Acute kidney injury (AKI) is a contributing factor in the development and progression of
chronic kidney disease (CKD). Despite rapid progresses, the mechanism underlying AKI …

Severe adverse systemic drug events occur commonly as a result of treatment of cancer
patients. Nephrotoxicity of chemotherapeutic agents remains a significant complication …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

The effectiveness of cisplatin, a mainstay in the treatment of many solid organ cancers, is
hindered by dose-limiting nephrotoxicity. Cisplatin causes AKI in 30% of patients. Patients …