Boosting Tadalafil Bioavailability via Sono-Assisted Nano-Emulsion-Based Oral Jellies: Box–Behnken Optimization and Assessment

HSM Ali, SA Ahmed, AA Alqurshi, AM Alalawi… - Pharmaceutics, 2022 - mdpi.com
Tadalafil (TAD) is a poorly soluble, phosphodiesterase inhibitor used to treat erectile
dysfunction. The primary goal of this project was to prepare nano-emulsions using ultrasonic …

[HTML][HTML] Development of a tadalafil transdermal formulation and evaluation of its ability to in vitro transdermal permeate using Strat-M® membrane

JS Sohn, JS Choi - European Journal of Pharmaceutical Sciences, 2024 - Elsevier
Tadalafil (TDF) has low water solubility, high intestinal permeability and belongs to the
Biopharmaceutics Classification System (BCS) Class II. Due to high intestinal permeability …

Locally Acting Budesonide-Loaded Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Distal Ulcerative Colitis

HSM Ali, AF Hanafy, R Bafail, H Alrbyawi… - International Journal …, 2024 - Taylor & Francis
Background Budesonide (BUD) is a BCS class II medication with poor water solubility and
limited oral bioavailability. In this study, innovative solid self-microemulsifying drug delivery …

Enhanced bioavailability and pharmacokinetics parameters of Enalapril solid self nanoemulsifying oral dispersible tablet: Formulation, in vitro and in vivo evaluation

DH Hassan, AA Ammar, AA Ramadan… - Pharmaceutical …, 2023 - Taylor & Francis
Enalapril (EN) is an antihypertensive drug that is sparingly soluble in water with limited oral
bioavailability. Successfully prepared self-nanoemulsifying systems (SNES) loaded with EN …

Erectile Dysfunction Therapy of Bariatric Patients: Tadalafil Biopharmaceutics and Pharmacokinetics Before vs. After Gastric Sleeve/Bypass

D Porat, O Dukhno, S Cvijić, A Dahan - The AAPS Journal, 2024 - Springer
Bariatric surgery introduces significant changes in the gastrointestinal tract, which may affect
oral drug absorption/bioavailability. Here we investigate the phosphodiesterase-5 inhibitor …

Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In …

KA Khan, A Ahmad, C Marini, M Nicotra, A Di Cerbo… - Pharmaceutics, 2024 - mdpi.com
In the current study, matrices of losartan potassium were formulated with two different
polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a …

Investigating in-vitro functionality and in-vivo taste assessment of eco-friendly Tadalafil Pastilles

H Rana, M Panchal, V Thakkar, T Gandhi, M Dholakia - Heliyon, 2024 - cell.com
Tadalafil (TDL) has poor bioavailability due to the less aqueous solubility and bitter taste.
Oral solid dosage forms, especially tablets, have a broad market worldwide. Constraints of …

Formulation and evaluation of in vitro antacid effect of effervescent granules containing extracts of Evolvulus alsinoides

W Jayasuriya, HUV Hettiarachchi, T Kumara… - … Journal of Sri Lanka, 2022 - pjsl.sljol.info
Purpose: This study investigates the in-vitro gastroprotective activity of the aqueous and
ethanolic extracts of Evolvulus alsinoides Linn plant and formulates an antacid dosage form …

[PDF][PDF] Research Article Formulation and evaluation of in vitro antacid effect of effervescent granules containing extracts of Evolvulus alsinoides

J WJABN, HUV Hettiarachchi, K TDMTS, NTB Dias… - researchgate.net
Purpose: This study investigated the in vitro antacid activity of aqueous and ethanolic
extracts of Evolvulus alsinoides Linn. plant and formulated an antacid dosage form …