Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

H Lin, Y Wang, P Wang, F Long, T Wang - Molecular cancer, 2022 - Springer
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …

Identification of lncRNA/circRNA-miRNA-mRNA ceRNA network as biomarkers for hepatocellular carcinoma

S Chen, Y Zhang, X Ding, W Li - Frontiers in genetics, 2022 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer, with
the incidence and mortality rates increasing every year. Despite the improvement of clinical …

Wnt/β-catenin signaling as a driver of hepatocellular carcinoma progression: an emphasis on molecular pathways

M Deldar Abad Paskeh, S Mirzaei… - Journal of …, 2021 - Taylor & Francis
Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is
considered as the most common primary liver cancer. HCC remains a challenging disease …

circFNDC3B accelerates vasculature formation and metastasis in oral squamous cell carcinoma

X Li, C Wang, H Zhang, Y Li, D Hou, D Liu, R Xu… - Cancer Research, 2023 - AACR
Emerging evidence has demonstrated that circular RNAs (circRNA) are involved in cancer
metastasis. Further elucidation of the role of circRNAs in oral squamous cell carcinoma …

CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to …

D Li, J Zhang, J Yang, J Wang, R Zhang, J Li… - Cell Death & …, 2021 - nature.com
CircRNA mitochondrial tRNA translation optimization 1 (circMTO1) functions as a tumor
suppressor usually and is related to the progression of many tumors, including …

Roles of exosomal circRNAs in tumour immunity and cancer progression

B Tuo, Z Chen, Q Dang, C Chen, H Zhang, S Hu… - Cell Death & …, 2022 - nature.com
Tumour immunity plays an important role in the development of cancer. Tumour
immunotherapy is an important component of antitumour therapy. Exosomes, a type of …

Hsa_circ_0046523 mediates an immunosuppressive tumor microenvironment by regulating MiR-148a-3p/PD-L1 axis in pancreatic cancer

X Fu, G Sun, S Tu, K Fang, Y Xiong, Y Tu, M Zha… - Frontiers in …, 2022 - frontiersin.org
Background Circular RNAs (circRNAs) are a novel type of non-coding RNA, play an
important role in the progression of tumors. However, the function and mechanism of …

ALKBH5‐induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2

X Ji, C Lv, J Huang, W Dong, W Sun… - Cancer Science, 2023 - Wiley Online Library
Although circular RNAs (circRNAs) are involved in cell proliferation, differentiation,
apoptosis, and invasion, the underlying regulatory mechanisms of circRNAs in thyroid …