Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Objectives: Chronic pain places a burden on individuals and the economy. Although there is
evidence for the effectiveness of cognitive-behavior therapy, it is recognized that the effects …

Background Spinal cord stimulation has been an established treatment for chronic back and
leg pain for more than 50 years; however, outcomes are variable and unpredictable, and …

Purpose To provide evidence-based guidance on the optimum prevention and treatment
approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) …

Importance There are no known effective treatments for painful chemotherapy-induced
peripheral neuropathy. Objective To determine the effect of duloxetine, 60 mg daily, on …

Background This is an updated version of the original Cochrane Review published in 2010,
Issue 9, and last updated in 2014, Issue 4. Non‐invasive brain stimulation techniques aim to …

Background Neuropathic pain, which is due to nerve disease or damage, represents a
significant burden on people and society. It can be particularly unpleasant and achieving …

Background Pharmacotherapy remains an important modality for the treatment of
neuropathic pain. However, as monotherapy current drugs are associated with limited …

Background There is currently no strong consensus regarding the optimal management of
complex regional pain syndrome although a multitude of interventions have been described …

Background Complex regional pain syndrome (CRPS) is a painful and disabling condition
that usually manifests in response to trauma or surgery and is associated with significant …