Ultrasonic energy for construction of bioactive heterocycles

O Kamble, R Chatterjee, R Dandela, S Shinde - Tetrahedron, 2022 - Elsevier
The ultrasonic energy has been revisited and applied for the synthesis of bioactive
molecules in a short time and green method. These compounds can exhibit anticancer …

Anticancer drug design using scaffolds of β-lactams, sulfonamides, quinoline, quinoxaline and natural products. Drugs advances in clinical trials

I Balderas-Renteria… - Current medicinal …, 2012 - benthamdirect.com
Eleven years after the start of a new millennium characterized by amazing scientific
development, the cure for cancer remains a major challenge for humanity. In this regard …

Experimental and theoretical investigation for 6-Morpholinosulfonylquinoxalin-2 (1H)-one and its haydrazone derivate: Synthesis, characterization, tautomerization …

DM Elsisi, A Ragab, AA Elhenawy, AA Farag… - Journal of Molecular …, 2022 - Elsevier
This work aimed to synthesize a safe antimicrobial agent based on dihydroquinoxalinedione
derivatives. The structure of the synthesized compounds was established based on different …

Isatin derived spirocyclic analogues with α-methylene-γ-butyrolactone as anticancer agents: a structure–activity relationship study

S Rana, EC Blowers, C Tebbe… - Journal of medicinal …, 2016 - ACS Publications
Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their
evaluation as anticancer agents is described. SAR identified a spirocyclic analogue 19 that …

Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

DC Alexander, T Corman, M Mendoza… - Proceedings of the …, 2022 - National Acad Sciences
Histone acetylation is a key component in the consolidation of long-term fear memories.
Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear …

Synthesis and biological evaluation of novel 2, 3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents

J Cogo, V Kaplum, DP Sangi, T Ueda-Nakamura… - European Journal of …, 2015 - Elsevier
Quinoxalines belong to the N-containing heterocyclic compounds that stand out as having
promising biological activity due to their privileged scaffold. In this work, we report the …

CO 2-assisted synthesis of non-symmetric α-diketones directly from aldehydes via C–C bond formation

P Hirapara, D Riemer, N Hazra, J Gajera, M Finger… - Green …, 2017 - pubs.rsc.org
CO2-assisted various symmetric and non-symmetric α-diketones have been synthesized
directly from the corresponding aldehydes using transition metal-free catalysts. This method …

Experimental and theoretical investigations for novel 6-nitroquinoxaline-2, 3‑dione derivatives: Synthesis, characterization, DFT calculations, ADME analysis, hirshfeld …

Y Seqqat, H El Monfalouti, S Laaraj, JT Mague… - Journal of Molecular …, 2025 - Elsevier
This work describes the synthesis of eight different 6-nitro-1, 4-disubstituted-quinoxaline-2, 3‑
dione derivatives (4a-h). The starting material, 6-nitroquinoxaline-2, 3‑dione 3 was prepared …

CO2-catalyzed/promoted transformation of organic functional groups

W Schilling, S Das - Tetrahedron Letters, 2018 - Elsevier
Carbon dioxide is a cheap, non-toxic, abundant chemical and has been widely utilized in
organic syntheses. Many new strategies have been developed using CO 2 as a C1 building …

Liposome-based nanocarrier loaded with a new quinoxaline derivative for the treatment of cutaneous leishmaniasis

JK de Oliveira, T Ueda-Nakamura, AG Correa… - Materials Science and …, 2020 - Elsevier
The use of nanocarriers for drug delivery is a strategy aimed to improve therapeutic indices
through changes in their pharmacokinetic and pharmacodynamic characteristics. Liposomes …