Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function

HY Kim, JW Um, J Ko - Progress in Neurobiology, 2021 - Elsevier
Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

The role of zinc and NMDA receptors in autism spectrum disorders

K Lee, Z Mills, P Cheung, JE Cheyne, JM Montgomery - Pharmaceuticals, 2022 - mdpi.com
NMDA-type glutamate receptors are critical for synaptic plasticity in the central nervous
system. Their unique properties and age-dependent arrangement of subunit types underpin …

[HTML][HTML] Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition

A Yu, J Hu, L Fu, G Huang, D Deng… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Immune checkpoint inhibitor (ICI) therapy improves the survival of patients with
advanced bladder cancer (BLCA); however, its overall effectiveness is limited, and many …

The role of synaptic cell adhesion molecules and associated scaffolding proteins in social affiliative behaviors

SC Taylor, SL Ferri, M Grewal, Z Smernoff, M Bucan… - Biological …, 2020 - Elsevier
Social affiliative behaviors—engagement in positive (ie, nonaggressive) social approach
and reciprocal social interactions with a conspecific—comprise a construct within the …

Arc regulates transcription of genes for plasticity, excitability and Alzheimer's disease

HW Leung, G Foo, A VanDongen - Biomedicines, 2022 - mdpi.com
The immediate early gene Arc is a master regulator of synaptic function and a critical
determinant of memory consolidation. Here, we show that Arc interacts with dynamic …

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

JR Thompson, ED Nelson, M Tippani, AD Ramnauth… - BioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The hippocampus contains many unique cell types, which serve the structure's specialized
functions, including learning, memory and cognition. These cells have distinct spatial …

Information sharing within a social network is key to behavioral flexibility—Lessons from mice tested under seminaturalistic conditions

M Winiarski, A Madecka, A Yadav, J Borowska… - Science …, 2025 - science.org
Being part of a social structure offers chances for social learning vital for survival and
reproduction. Nevertheless, studying the neural mechanisms of social learning under …

Single-cell multi-omic roadmap of human fetal pancreatic development

O Sean, Z Liu, H Sun, SK Yu, DM Wong, E Chu… - BioRxiv, 2022 - biorxiv.org
The critical cellular transitions that govern human pancreas development are largely
unknown. We performed large-scale single-cell RNA-sequencing (scRNA-Seq) to …

Interplay between genome-wide implicated genetic variants and environmental factors related to childhood antisocial behavior in the UK ALSPAC cohort

IH Ruisch, A Dietrich, JC Glennon, JK Buitelaar… - European archives of …, 2019 - Springer
We investigated gene–environment (G× E) interactions related to childhood antisocial
behavior between polymorphisms implicated by recent genome-wide association studies …

Quantitative proteomics reveals significant differences between mouse brain formations in expression of proteins involved in neuronal plasticity during aging

D Drulis-Fajdasz, K Gostomska-Pampuch, P Duda… - Cells, 2021 - mdpi.com
Aging is associated with a general decline in cognitive functions, which appears to be due to
alterations in the amounts of proteins involved in the regulation of synaptic plasticity. Here …