[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
The proteolytic regulation of virus cell entry by furin and other proprotein convertases
G Izaguirre - Viruses, 2019 - mdpi.com
A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
G Papa, DL Mallery, A Albecka, LG Welch… - PLoS …, 2021 - journals.plos.org
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to
the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered …
the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered …
The proprotein convertase furin in cancer: More than an oncogene
Z He, AM Khatib, JWM Creemers - Oncogene, 2022 - nature.com
Furin is the first discovered proprotein convertase member and is present in almost all
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …
mammalian cells. Therefore, by regulating the maturation of a wide range of proproteins …
Roles of host proteases in the entry of SARS-CoV-2
A Zabiegala, Y Kim, KO Chang - Animal Diseases, 2023 - Springer
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …
Evolution of the SARS‐CoV‐2 proteome in three dimensions (3D) during the first 6 months of the COVID‐19 pandemic
Understanding the molecular evolution of the SARS‐CoV‐2 virus as it continues to spread in
communities around the globe is important for mitigation and future pandemic …
communities around the globe is important for mitigation and future pandemic …
SARS-CoV-2 and emerging variants: unmasking structure, function, infection, and immune escape mechanisms
J Li, H Jia, M Tian, N Wu, X Yang, J Qi… - Frontiers in Cellular …, 2022 - frontiersin.org
As of April 1, 2022, over 468 million COVID-19 cases and over 6 million deaths have been
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …
Why all the fury over furin?
EEA Osman, A Rehemtulla… - Journal of medicinal …, 2021 - ACS Publications
Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the
S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best …
S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best …
PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries
PepSeq is an in vitro platform for building and conducting highly multiplexed proteomic
assays against customizable targets by using DNA-barcoded peptides. Starting with a pool …
assays against customizable targets by using DNA-barcoded peptides. Starting with a pool …
Altered islet prohormone processing: a cause or consequence of diabetes?
A Ramzy, TJ Kieffer - Physiological reviews, 2022 - journals.physiology.org
Peptide hormones are first produced as larger precursor prohormones that require
endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but …
endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but …