Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

SC Cunnane, E Trushina, C Morland… - Nature reviews Drug …, 2020 - nature.com
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

AA Shaimardanova, VV Solovyeva… - Neural regeneration …, 2020 - journals.lww.com
Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the
activity of the nervous system, participating in signal transmission between neurons and …

The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease

S Candido, G Lupo, M Pennisi… - Oncology …, 2019 - spandidos-publications.com
There is recent evidence to indicate the existence of an inverse association between the
incidence of neurological disorders and cancer development. Concurrently, the …

Gene therapy: A promising approach for breast cancer treatment

NT Dastjerd, A Valibeik… - Cell biochemistry …, 2022 - Wiley Online Library
Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death
among women worldwide that is caused by numerous genetic and environmental factors …

Long noncoding RNAs in neurodevelopment and Parkinson's disease

Y Lyu, L Bai, C Qin - Animal models and experimental …, 2019 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are RNA molecules comprising more than 200
nucleotides, which are not translated into proteins. Many studies have shown that lncRNAs …

Small non-coding RNA transcriptomic profiling in adult and fetal human brain

M Smal, D Memoli, E Alexandrova, D Di Rosa… - Scientific Data, 2024 - nature.com
Small non-coding RNAs (sncRNAs) make up~ 1% of the transcriptome; nevertheless, they
play significant roles in regulating cellular processes. Given the complexity of the central …

miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role

Q Yang, Q Zhao, Y Yin - Experimental and Therapeutic …, 2019 - spandidos-publications.com
MicroRNAs (miRNAs/miRs) are involved in post‑transcriptional gene regulation and
aberrant expression of miRNAs has been widely detected in various human diseases. The …

Extracellular RNAs as biomarkers of sporadic amyotrophic lateral sclerosis and other neurodegenerative diseases

T Hosaka, T Yamashita, A Tamaoka… - International Journal of …, 2019 - mdpi.com
Recent progress in the research for underlying mechanisms in neurodegenerative diseases,
including Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral …

SNHG1 promotes MPP+-induced cytotoxicity by regulating PTEN/AKT/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p

J Zhao, L Geng, Y Chen, C Wu - Biological Research, 2020 - Springer
Background Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was
previously identified to be relevant with Parkinson's disease (PD) pathogenesis. This work …

Novel insights into the interaction between long non-coding RNAs and microRNAs in glioma

A Ebrahimpour, M Sarfi, S Rezatabar… - Molecular and cellular …, 2021 - Springer
Glioma is the most common brain tumor of the central nervous system. Long non-coding
RNAs (lncRNAs) and microRNAs (miRNAs) have been identified to play a vital role in the …