The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

Cellular proteins called" restriction factors" can serve as powerful blockades to HIV
replication, but the virus possesses elaborate strategies to circumvent these barriers. First …

Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022,
dozens of non-endemic countries reported hundreds of monkeypox cases, most with no …

The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …

Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …

Several recent studies have converged upon the innate immune DNA cytosine deaminase
APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in …

Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …

APOBEC3 (A3) genes are members of the AID/APOBEC gene family that are found
exclusively in mammals. A3 genes encode antiviral proteins that restrict the replication of …

The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …

ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …