Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Abstract Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much
attention because of its incredible roles in tissue differentiation, regeneration, and neural …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …

Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic
cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the …

The demonstration of protein sequence and functional homology of the Caenorhabditis
elegans programmed cell death gene product, CED-3, with human caspase-1 in 1993 …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The importance of the p53 protein in the cellular response to DNA damage is well known,
but its function during steady-state hematopoiesis has not been established. We have …

The mitochondrial caspase cascade was originally thought to be required for apoptotic
death driven by Bak/Bax-mediated intrinsic apoptosis. It has also been ascribed several 'non …

The genetic events that contribute to the pathogenesis of acute myeloid leukemia are among
the best characterized of all human malignancies. However, with notable exceptions such as …