In the past decade, relative proteomic quantification using isobaric labeling technology has
developed into a key tool for comparing the expression of proteins in biological samples …

Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Reduction and alkylation of cysteine residues is part of virtually any proteomics workflow.
Despite its frequent use, up to date no systematic investigation of the impact of different …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

Mass spectrometry is a highly complex analytical technique and mass spectrometry‐based
proteomics experiments can be subject to a large variability, which forms an obstacle to …

Complex diseases are caused by a combination of genetic and environmental factors,
creating a difficult challenge for diagnosis and defining subtypes. This review article …

Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–
1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments …

Discovery-based proteomics has found its place in nearly every facet of biological research.
A key objective of this approach is to maximize sequence coverage for proteins across a …

There are only 30,000 human genes, which, according to the central dogma from biology, it
means that there should be 30,000 mRNA and 30,000 proteins. However, there are at least …