Buruli ulcer: a review of the current knowledge

RR Yotsu, K Suzuki, RE Simmonds, R Bedimo… - … tropical medicine reports, 2018 - Springer
Abstract Purpose of the Review Buruli ulcer (BU) is a necrotizing and disabling cutaneous
disease caused by Mycobacterium ulcerans, one of the skin-related neglected tropical …

The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

TW Winkler, AE Justice, M Graff, L Barata… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI …

Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease)

RR Yotsu, M Richardson, N Ishii - Cochrane Database of …, 2018 - cochranelibrary.com
Background Buruli ulcer is a necrotizing cutaneous infection caused by infection with
Mycobacterium ulcerans bacteria that occurs mainly in tropical and subtropical regions. The …

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 …

RO Phillips, J Robert, KM Abass, W Thompson… - The Lancet, 2020 - thelancet.com
Background Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans
infection that damages the skin and subcutis. It is most prevalent in western and central …

[HTML][HTML] Buruli ulcer control in a highly endemic district in Ghana: role of community-based surveillance volunteers

KM Abass, TS Van Der Werf, RO Phillips… - The American journal …, 2015 - ncbi.nlm.nih.gov
Buruli ulcer (BU) is an infectious skin disease that occurs mainly in West and Central Africa.
It can lead to severe disability and stigma because of scarring and contractures. Effective …

Epidemiology and management of Buruli ulcer

GKL Huang, PDR Johnson - Expert review of anti-infective therapy, 2014 - Taylor & Francis
Buruli ulcer (Mycobacterium ulcerans infection) is a neglected tropical disease of skin and
subcutaneous tissue that can result in long-term cosmetic and functional disability. It is a …

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions

J Ogbechi, MT Ruf, BS Hall, K Bodman-Smith… - PLoS …, 2015 - journals.plos.org
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative
necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the …

Loop-mediated isothermal amplification for laboratory confirmation of Buruli ulcer disease—towards a point-of-care test

M Beissner, RO Phillips, F Battke, M Bauer… - PLoS Neglected …, 2015 - journals.plos.org
Background As the major burden of Buruli ulcer disease (BUD) occurs in remote rural areas,
development of point-of-care (POC) tests is considered a research priority to bring …

Increasing experience with primary oral medical therapy for Mycobacterium ulcerans disease in an Australian cohort

ND Friedman, E Athan, AL Walton… - Antimicrobial agents and …, 2016 - Am Soc Microbiol
Buruli ulcer (BU) is a necrotizing infection of subcutaneous tissue that is caused by
Mycobacterium ulcerans and is responsible for disfiguring skin lesions. The disease is …

Shortening Buruli ulcer treatment with combination therapy targeting the respiratory chain and exploiting Mycobacterium ulcerans gene decay

PJ Converse, DV Almeida, S Tyagi, J Xu… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Buruli ulcer is treatable with antibiotics. An 8-week course of rifampin (RIF) and either
streptomycin (STR) or clarithromycin (CLR) cures over 90% of patients. However, STR …