MMPs and TIMPs expression levels in the periodontal ligament during orthodontic tooth movement: a systematic review of in vitro and in vivo studies

C Behm, M Nemec, F Weissinger, MA Rausch… - International Journal of …, 2021 - mdpi.com
Background: During orthodontic tooth movement (OTM), applied orthodontic forces cause an
extensive remodeling of the extracellular matrix (ECM) in the periodontal ligament (PDL) …

Periodontal cell mechanotransduction

SS Chukkapalli, TP Lele - Open Biology, 2018 - royalsocietypublishing.org
The periodontium is a structurally and functionally complex tissue that facilitates the
anchorage of teeth in jaws. The periodontium consists of various cell types including stem …

Interleukin-1β induced matrix metalloproteinase expression in human periodontal ligament-derived mesenchymal stromal cells under in vitro simulated static …

C Behm, M Nemec, A Blufstein, M Schubert… - International Journal of …, 2021 - mdpi.com
The periodontal ligament (PDL) responds to applied orthodontic forces by extracellular
matrix (ECM) remodeling, in which human periodontal ligament-derived mesenchymal …

Fluid shear stress regulates metalloproteinase-1 and 2 in human periodontal ligament cells: involvement of extracellular signal-regulated kinase (ERK) and P38 …

L Zheng, Y Huang, W Song, X Gong, M Liu, X Jia… - Journal of …, 2012 - Elsevier
Matrix metalloproteinase (MMP)-1, 2, with their endogenous inhibitors, tissue inhibitor of
metalloproteinase (TIMP)-1, 2 are critical for extracellular matrix remodeling in human …

Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts

J Min, B Li, C Liu, W Guo, S Hong… - Molecular …, 2017 - spandidos-publications.com
Pelvic organ prolapse (POP) is a global health problem that may seriously impact the quality
of life of the sufferer. The present study aimed to investigate the potential mechanisms …

Toll-like receptor activation and mechanical force stimulation promote the secretion of matrix metalloproteinases 1, 3 and 10 of human periodontal fibroblasts via p38 …

RA Lisboa, MV Andrade, JR Cunha-Melo - Archives of Oral Biology, 2013 - Elsevier
Matrix metalloproteinases (MMPs) are known to play a key role during orthodontic treatment
leading to periodontal remodelling and tooth movement. MMPs may be induced by …

Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts

AC Tamashunas, A Katiyar, Q Zhang… - Journal of cellular …, 2021 - Wiley Online Library
Periodontal ligament fibroblasts (PdLFs) are an elongated cell type in the periodontium with
matrix and bone regulatory functions which become abnormal in periodontal disease (PD) …

Histochemical examination of cathepsin K, MMP1 and MMP2 in compressed periodontal ligament during orthodontic tooth movement in periostin deficient mice

S Lv, H Liu, J Cui, T Hasegawa, H Hongo… - Journal of molecular …, 2014 - Springer
The purpose of this study was to investigate immunolocalization of collagenolytic enzymes
including cathepsin K, matrix metalloproteinase (MMP) 1 and 2 in the compressed …

Extracellular Matrix Remodelling of the Periodontium under Orthodontic Force.

QY Yu, YP Huang, WR Li - Chinese Journal of Dental …, 2024 - search.ebscohost.com
As the biological mechanisms of orthodontic tooth movement have been explored further,
scholars have gradually focused on the remodelling mechanism of the extracellular matrix …

[HTML][HTML] Zimography is an effective method for detection of matrix metalloproteinase 2 (MMP-2) activity in cultured human fibroblasts

RA Lisboa, MV Andrade, JR Cunha-Melo - Acta Cirúrgica Brasileira, 2013 - SciELO Brasil
PURPOSE: To describe a method to characterize the gelatinase activity of cultured human
periodontal fibroblasts stimulated with Pam3Cys and E. coli LPS, ligands of TLR2 and TLR4 …