The gut microbiota is a key player in many physiological and pathological processes
occurring in humans. Recent investigations suggest that the efficacy of some clinical …

Antibiotics have been a cornerstone of innovation in the fields of public health, agriculture,
and medicine. However, recent studies have shed new light on the collateral damage they …

The optimism of the early period of antimicrobial discovery has been tempered by the
emergence of bacterial strains with resistance to these therapeutics. Today, clinically …

One potential outcome of the adaptive coevolution of humans and bacteria is the
development of commensal relationships, where neither partner is harmed, or symbiotic …

Despite increasing concerns over inappropriate use of antibiotics in medicine and food
production, population-level resistance transfer into the human gut microbiota has not been …

The intense use and misuse of antibiotics are undoubtedly the major forces associated with
the high numbers of resistant pathogenic and commensal bacteria worldwide. Both the …

To identify factors that regulate gut microbiota density and the impact of varied microbiota
density on health, we assayed this fundamental ecosystem property in fecal samples across …

Ubiquitous in nature, antimicrobial resistance (AMR) has existed long before the golden age
of antimicrobials. While antimicrobial agents are beneficial to combat infection, their …

The discovery of antibiotics heralded medicine's triumph over previously fatal diseases that
once destroyed entire civilizations-thus earning their reputation as miracle drugs. But today …

Bacterial resistance presents therapeutic dilemmas to clinicians worldwide. The warnings
were there long ago, but too few people heeded them. Thus an emerging problem has …