Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

V Panwar, A Singh, M Bhatt, RK Tonk… - Signal transduction and …, 2023 - nature.com
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Multifunctional biomolecule nanostructures for cancer therapy

J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Natural biodegradable polymers based nano-formulations for drug delivery: A review

A George, PA Shah, PS Shrivastav - International journal of pharmaceutics, 2019 - Elsevier
Nanomedicines are now considered as the new-generation medication in the current era
mainly because of their features related to nano size. The efficacy of many drugs in their …

Research progress of mTOR inhibitors

Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

Cancer drug delivery in the nano era: An overview and perspectives

Z Li, S Tan, S Li, Q Shen, K Wang - Oncology reports, 2017 - spandidos-publications.com
Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials
also appeal to researchers in the areas of cancer diagnosis and biomarker discovery …

Clinical translation of nanomedicine

Y Min, JM Caster, MJ Eblan, AZ Wang - Chemical reviews, 2015 - ACS Publications
Clinical Translation of Nanomedicine | Chemical Reviews ACS ACS Publications C&EN CAS
Find my institution Log In Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most …

Rapamycin passes the torch: a new generation of mTOR inhibitors

D Benjamin, M Colombi, C Moroni… - Nature reviews Drug …, 2011 - nature.com
Mammalian target of rapamycin (mTOR) is an atypical protein kinase that controls growth
and metabolism in response to nutrients, growth factors and cellular energy levels, and it is …

Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers

FM Kievit, M Zhang - Advanced materials, 2011 - Wiley Online Library
Cancer nanotheranostics aims to combine imaging and therapy of cancer through use of
nanotechnology. The ability to engineer nanomaterials to interact with cancer cells at the …

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

N Mimura, M Fulciniti, G Gorgun, YT Tai… - Blood, The Journal …, 2012 - ashpublications.org
Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic
endoplasmic reticulum (ER) stress, which is adaptively managed by the unfolded protein …