Background Hepatocellular carcinoma (HCC) is still a major health problem, often
diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole …

RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …

Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans.
The molecular mechanisms leading to the development of HCC are extremely complicated …

Purpose Hepatocellular carcinoma (HCC) is a common and deadly malignancy with few
systemic therapy options. The RAF/mitogen-activated protein kinase kinase …

Human pituitary adenomas are the most common intracranial neoplasms. Approximately 5%
of them are familial adenomas. Patients with familial tumors carry germline mutations in …

Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic,
lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches …

Background & Aims Overexpression of FoxM1 correlates with poor prognosis in
hepatocellular carcinoma (HCC). Moreover, the Ras-signaling pathway is found to be …

In human hepatocellular carcinoma (HCC), epithelial to mesenchymal transition (EMT)
correlates with aggressiveness of tumors and poor survival. We employed a model of EMT …