The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

The transforming growth factor β (TGF-β) family controls many fundamental aspects of
cellular behavior. With advances in the molecular details of the TGF-β signaling cascade …

Except for an essential step for the pathology of multiple diseases including atherosclerosis
and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing …

Recent molecular classifications of colorectal cancer (CRC) based on global gene
expression profiles have defined subtypes displaying resistance to therapy and poor …

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …