Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Highlights•On average, one cyclic peptide drug is approved every year.•New strategies
based on rational design and in vitro evolution deliver peptides to new targets.•Many of the …

Axially chiral diaryl ethers are a type of unique atropisomers bearing two potential axes,
which have potential applications in a variety of research fields. However, the catalytic …

Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …

Chirality plays a crucial role in life-sustaining processes, and for this reason asymmetric
synthesis has been a central research theme in many research groups in the field of organic …

Axially chiral diaryl ethers, a distinguished class of atropisomers possessing unique dual C−
O axis, hold immense potential for diverse research domains. In contrast to the catalytic …

In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an
increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold …

Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant
bacteria, with vancomycin still a mainstream therapy against serious Gram-positive …

Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

The biaryl structural motif is a predominant feature in many pharmaceutically relevant and
biologically active compounds. As a result, for over a century1 organic chemists have sought …