Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Differentiation of hematopoietic stem and progenitor cells is tightly regulated depending on
environmental changes in order to maintain homeostasis. Transcription factors direct the …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

Simple Summary Chronic lymphocytic leukaemia (CLL) is the most frequent type of
leukaemia with a highly variable presentation, clinical course, and outcome. The overall aim …

Human immune system functions over an entire lifetime, yet how and why the immune
system becomes less effective with age are not well understood. Here, we characterize …

Bach2 was initially discovered in B cells, where it was revealed to control the transcription
involved in cell differentiation. Bach2 is intimately connected to CD8+ T lymphocytes in …

Alternative glycosylation of immunoglobulin G (IgG) affects its effector functions during the
immune response. IgG glycosylation is altered in many diseases, but also during a healthy …

Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease;
the majority of patients eventually acquire resistance to treatment through relapses. In all …

Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated
immune regulation. Effector CTLs derived from in vitro activation of murine CD8+ T cells …

Older age is one of the most important shared risk factors for multiple chronic diseases,
increasing the medical burden to contemporary societies. Current research focuses on …