Enzymes as drugs have two important features that distinguish them from all other types of
drugs. First, enzymes often bind and act on their targets with great affinity and specificity …

Background Clinical experience and existing research strongly support debridement as a
necessary component of wound bed preparation when slough or eschar is present. Multiple …

Abstract Introduction Bromelain-based Enzymatic Debridement has been introduced as an
additional concept to the burn surgeon's armamentarium and is best indicated for mid-to …

Collagen and hyaluronan are the most abundant components of the extracellular matrix
(ECM) and their overexpression in tumors is linked to increased tumor growth and …

It is currently challenging to eradicate cancer. In the case of solid tumors, the dense and
aberrant extracellular matrix (ECM) is a major contributor to the heterogeneous distribution …

A prospective, non-comparative study design was used to describe our experience with a
bromelain-derived debriding agent, Debridase, in 130 patients with 332 deep second …

Early debridement and/or eschar removal is regarded as a significant step in the treatment of
deep partial and full thickness burns. It aims to control wound bioburden and allows early …

A large part of the patient population of a burn centre consists of children, most of whom are
younger than four years. The majority of these young children suffer from superficial and …

It is not the presence of microorganisms, but their interaction with patients that determines
their influence on wound healing. Documenting this critical but often ignored aspect of the …

BACKGROUND: The burned hand is a common and difficult to care-for entity in the field of
burns. Due to the anatomy of the hand (important and delicate structures crowded in a small …