Simple Summary New methodologies and technologies developed in the last few decades
have highlighted the precise spatial organization of the genome into the cell nucleus, with …

The packaging of the eukaryotic genome into chromatin regulates the storage of genetic
information, including the access of the cell's DNA metabolism machinery. Indeed, since the …

The active transport of large biomolecules within a cell is critical for homeostasis. While the
cytoplasmic process is well-studied, how the spacing of nucleoplasmic cargo is coordinated …

In encoding the fundamental information to create a cognate cell, genomes are often
referred to as the blueprints of life. Yet, a perfunctory consideration of a common blueprint …

I began my graduate research with a study of Chromatin remodelers, which are
molecularmotors that play essential roles in the regulation of nucleosome positioning and …

Cells in their natural setting harmonize structure and function in a way that makes them
instantly recognizable—think of a neuron, for instance, or a budding yeast. Yet the apparent …

Epigenetic modifications are involved in the maintenance of tissues, achieved without the
need to alter the underlying genomic sequence. In this thesis, I focus on DNA methylation …