Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Pathophysiology and treatment of cerebral edema in traumatic brain injury

RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy

E Edlmann, S Giorgi-Coll, PC Whitfield… - Journal of …, 2017 - Springer
Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on
the surface of the brain. Historically considered a result of head trauma, recent evidence …

Microglial activation in traumatic brain injury

CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

Mechanisms of blood–brain barrier dysfunction in traumatic brain injury

A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Factors controlling permeability of the blood–brain barrier

MMA Almutairi, C Gong, YG Xu, Y Chang… - Cellular and molecular life …, 2016 - Springer
As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB)
exists between the blood microcirculation system and the brain parenchyma. The normal …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

Bioactive injectable hydrogels for on demand molecule/cell delivery and for tissue regeneration in the central nervous system

MA Grimaudo, GS Krishnakumar, E Giusto, F Furlani… - Acta biomaterialia, 2022 - Elsevier
Currently there are no potential curative therapies that can improve the central nervous
system (CNS) regeneration after traumatic injuries or diseases. Indeed, the regeneration of …

Extracellular matrix and traumatic brain injury

N George, HM Geller - Journal of neuroscience research, 2018 - Wiley Online Library
The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult
brain by providing structural support and mediating cell‐cell interactions. In this review, we …

Oxidative stress and the neurovascular unit

C Rinaldi, L Donato, S Alibrandi, C Scimone… - Life, 2021 - mdpi.com
The neurovascular unit (NVU) is a relatively recent concept that clearly describes the
relationship between brain cells and their blood vessels. The components of the NVU …