The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies,
including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 …

INTRODUCTION Aggregation of the RNA binding protein TDP-43 (TAR DNA-binding protein
43) is a common pathological hallmark shared by several age-related neurodegenerative …

Beige fat plays key roles in the regulation of systemic energy homeostasis; however,
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …

Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …

Stress granules (SGs) are transient ribonucleoprotein (RNP) aggregates that form during
cellular stress and are increasingly implicated in human neurodegeneration. To study the …

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

In recent years, m6A has emerged as an abundant and dynamically regulated modification
throughout the transcriptome. Recent technological advances have enabled the …

The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau
(oTau) are unknown. We have used Cry2-based optogenetics to induce tau oligomers (oTau …