Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae
JE Haber - Genetics, 2012 - academic.oup.com
Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …
The Establishment, Inheritance, and Function of Silenced Chromatin in Saccharomyces cerevisiae
▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …
regions known as heterochromatin, or silenced chromatin. This review describes …
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
M Kaeberlein, M McVey, L Guarente - Genes & development, 1999 - genesdev.cshlp.org
The SIR genes are determinants of life span in yeast mother cells. Here we show that life
span regulation by the Sir proteins is independent of their role in nonhomologous end …
span regulation by the Sir proteins is independent of their role in nonhomologous end …
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
RA Frye - Biochemical and biophysical research communications, 2000 - Elsevier
Sirtuins (Sir2-like proteins) are present in prokaryotes and eukaryotes. Here, two new
human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect …
human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect …
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP …
RA Frye - Biochemical and biophysical research communications, 1999 - Elsevier
The yeast Sir2 protein regulates epigenetic gene silencing and as a possible antiaging
effect it suppresses recombination of rDNA. Studies involving cobB, a bacterial SIR2-like …
effect it suppresses recombination of rDNA. Studies involving cobB, a bacterial SIR2-like …
Elevated histone expression promotes life span extension
Changes to the chromatin structure accompany aging, but the molecular mechanisms
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
JS Smith, CB Brachmann, I Celic… - Proceedings of the …, 2000 - National Acad Sciences
The yeast Sir2 protein, required for transcriptional silencing, has an NAD+-dependent
histone deacetylase (HDA) activity. Yeast extracts contain a NAD+-dependent HDA activity …
histone deacetylase (HDA) activity. Yeast extracts contain a NAD+-dependent HDA activity …
[HTML][HTML] Conserved histone variant H2A. Z protects euchromatin from the ectopic spread of silent heterochromatin
MD Meneghini, M Wu, HD Madhani - Cell, 2003 - cell.com
Boundary elements hinder the spread of heterochromatin, yet these sites do not fully
account for the preservation of adjacent euchromatin. Histone variant H2A. Z (Htz1 in yeast) …
account for the preservation of adjacent euchromatin. Histone variant H2A. Z (Htz1 in yeast) …
Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
R Visintin, ES Hwang, A Amon - Nature, 1999 - nature.com
In eukaryotes, the activation of mitotic cyclin-dependent kinases (CDKs) induces mitosis,
and their inactivation causes cells to leave mitosis. In budding yeast, two redundant …
and their inactivation causes cells to leave mitosis. In budding yeast, two redundant …