The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …

The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …

The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

The ever-increasing number of chemicals has raised public concerns due to their adverse
effects on human health and the environment. To protect public health and the environment …

In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such
methods is increasing in all applications but especially for regulatory submissions, such as …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …

Many nitrosamines are recognized as mutagens and potent rodent carcinogens. Over the
past few years, nitrosamine impurities have been detected in various drugs leading to drug …

Internationally, there are thousands of existing and newly introduced chemicals in
commerce, highlighting the ongoing importance of innovative approaches to identify …

Risk assessments are increasingly reliant on information from in vitro assays. The in vitro
micronucleus test (MNvit) is a genotoxicity test that detects chromosomal abnormalities …

Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with
sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment …