Roles and mechanisms of umbilical cord mesenchymal stem cells in the treatment of diabetic foot: a review of preclinical and clinical studies

H Zhang, Y Gu, K Zhang, Y Tu, C Ouyang - Journal of Diabetes and its …, 2024 - Elsevier
Aims Growing preclinical and clinical evidence has suggested the potential method of
umbilical cord mesenchymal stem cell (UCMSC) therapy for diabetic foot. Thus, the authors …

Mesenchymal stem cell in pancreatic islet transplantation

S Barachini, L Biso, S Kolachalam, I Petrini, R Maggio… - Biomedicines, 2023 - mdpi.com
Pancreatic islet transplantation is a therapeutic option for achieving physiologic regulation of
plasma glucose in Type 1 diabetic patients. At the same time, mesenchymal stem cells …

Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

X Li, D Zhang, Y Yu, L Wang, M Zhao - Cell Proliferation, 2024 - Wiley Online Library
How to effectively repair cutaneous wounds and promote skin rejuvenation has always been
a challenging issue for clinical medicine and medical aesthetics. Current conventional …

Therapeutic Potential of Mesenchymal Stem Cell‐Derived Conditioned Medium for Diabetes Mellitus and Related Complications

B Isildar, S Ozkan, M Koyuturk - Advanced Therapeutics, 2023 - Wiley Online Library
Diabetes mellitus (DM) is one of the most life‐threatening metabolic disorders, with 9% of
the global prevalence, and it is estimated to be rising to 12.2% in 2045. Currently, there is no …

hUC-MSCs therapy for Crohn's disease: efficacy in TNBS-induced colitis in rats and pilot clinical study

Q Sun, S Li, R Lin, G Zhao, J Lu, B Liu, M Hu… - Ebiomedicine, 2024 - thelancet.com
Background The use of mesenchymal stem cells (MSCs) has recently emerged as a
promising new therapeutic strategy for many diseases including perianal fistulizing Crohn's …

External application of human umbilical cord-derived mesenchymal stem cells in hyaluronic acid gel repairs foot wounds of types I and II diabetic rats through …

J Chen, Y Liu, J Zhang, Y Yang, H Liang… - Stem Cells …, 2023 - academic.oup.com
Diabetic foot ulcer (DFU) is a main diabetic complication with unmet treatment needs. This
study applied human umbilical cord-derived mesenchymal stem cells-hyaluronic acid …

[HTML][HTML] Immobilization of hUC-MSCs conditioned medium on 3D PLLA collagen-coated matrix enhances diabetic wound healing progression

S Hendrawan, O Marcelina, ST Tan, HU Baer - Engineered Regeneration, 2024 - Elsevier
Conditioned medium (CM) derived from human umbilical cord-mesenchymal stem cells
(hUC-MSCs) which contains numerous amounts of growth factors, has demonstrated …

Therapeutic Efficacy of Interferon-Gamma and Hypoxia-Primed Mesenchymal Stromal Cells and Their Extracellular Vesicles: Underlying Mechanisms and Potentials …

YL Tan, ME Al-Masawa, SP Eng, MN Shafiee, JX Law… - Biomedicines, 2024 - mdpi.com
Multipotent mesenchymal stromal cells (MSCs) hold promises for cell therapy and tissue
engineering due to their self-renewal and differentiation abilities, along with …

Wound-healing effects of mesenchymal stromal cell secretome in the cornea and the role of exosomes

S An, K Anwar, M Ashraf, H Lee, R Jung, R Koganti… - Pharmaceutics, 2023 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) and their secreted factors have been shown to
have immunomodulatory and regenerative effects. In this study, we investigated human …

Fibroblast matrix implants—a better alternative for incisional hernia repair?

S Hendrawan, J Lheman, U Weber… - Biomedical …, 2024 - iopscience.iop.org
The standard surgical procedure for abdominal hernia repair with conventional prosthetic
mesh still results in a high recurrence rate. In the present study, we propose a fibroblast …