Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins.
Their intriguing chemical structural diversification and complexity, potential bioactivities, and …

Hydrogen atom transfer (HAT) hydrogenation has recently emerged as an indispensable
method for the chemoselective reduction of unactivated alkenes. However, the hitherto …

Polycyclic diterpenes exhibit many important biological activities, but de novo synthetic
access to these molecules is highly challenging because of their structural complexity …

The metal-hydride hydrogen atom transfer (MHAT) reaction plays an important role in the
field of natural product synthesis. MHAT, as a powerful method, has been employed by …

The synthesis of steroid drugs by multistage modifications of the steroidal core is
challenging since site-specific and selective modification is essentially required, which is …