HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways

C Bao, S Zhu, K Song, C He - Cell Communication and Signaling, 2022 - Springer
Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …

The contribution of whole-exome sequencing to intellectual disability diagnosis and knowledge of underlying molecular mechanisms: A systematic review and meta …

KY Sanchez-Luquez, MX Carpena, SM Karam… - … Research/Reviews in …, 2022 - Elsevier
Whole-exome sequencing (WES) is useful for molecular diagnosis, family genetic
counseling, and prognosis of intellectual disability (ID). However, ID molecular diagnosis …

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription

L Jin, Q Tang, S Hu, Z Chen, X Zhou, B Zeng… - Nature …, 2021 - nature.com
A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of
tissue specialization processes underlying economically valuable traits and accelerate their …

Coupling of GABA metabolism to mitochondrial glucose phosphorylation

JP Cavalcanti-de-Albuquerque… - Neurochemical …, 2021 - Springer
Glucose and oxygen (O 2) are vital to the brain. Glucose metabolism and mitochondria play
a pivotal role in this process, culminating in the increase of reactive O 2 species. Hexokinase …

Proteomic analysis of zebrafish brain damage induced by Microcystis aeruginosa bloom

Y Yu, Q Zhang, G Liu, Y Deng, J Kang, F Zhang… - Science of the Total …, 2021 - Elsevier
Cyanobacterial blooms constitute a global ecological problem that can seriously threaten
human health. One of the most common bloom-forming cyanobacteria in freshwater is …

[HTML][HTML] Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies

AD Medyanik, PE Anisimova, AO Kustova… - Biomolecules, 2025 - mdpi.com
Developmental and epileptic encephalopathies (DEEs) are a group of neuropediatric
diseases associated with epileptic seizures, severe delay or regression of psychomotor …

A de novo hexokinase 1 (HK1) variant presenting as Boucher–Neuhäuser syndrome

RH Peretz, WM Zein, RB Hufnagel, C Ku… - American Journal of …, 2023 - Wiley Online Library
Boucher–Neuhäuser syndrome (BNHS) is characterized by chorioretinal dystrophy,
hypogonadotropic hypogonadism, and cerebellar dysfunction and atrophy. The disorder has …

[HTML][HTML] Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells

G Assis-de-Lemos, J Monteiro… - Bioscience …, 2021 - portlandpress.com
Dopamine signaling has numerous roles during brain development. In addition, alterations
in dopamine signaling may be also involved in the pathophysiology of psychiatric disorders …

HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia

Q Tang, Q Xu, C Ding, H Zhang… - American Journal of …, 2021 - journals.physiology.org
The Tibetan chicken (Gallus gallus; TBC) is an indigenous breed found in the Qinghai-Tibet
Plateau that are well adapted to a hypoxic environment. The energy metabolism of …

The Role of HK2 in Tumorigenesis and Development: Potential for Targeted Therapy with Natural Products

K He, F Tao, Y Lu, M Fang, H Huang… - International Journal of …, 2025 - medsci.org
Abstract Hexokinase 2 (HK2) is widely distributed in various tissues, particularly showing
significantly elevated expression levels in tumor tissues. As the initial rate-limiting enzyme in …