Gaucher disease (GD) is an autosomal recessive inherited lysosomal storage disease that
often presents in early childhood and is associated with damage to multiple organ systems …

Progranulin (PGRN), a widely expressed glycoprotein with pleiotropic function, has been
linked to a host of physiological processes and diverse pathological states. A series of …

Long‐term or severe lack of protective factors is important in the pathogenesis of
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …

Background: Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal
dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40 and …

Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth
factor and acts as a universal regulator of cell growth, migration and transformation, cell …

Adipokines are protein hormones secreted by adipose tissue in response to disruptions in
physiological homeostasis within the body's systems. The regulatory functions of adipokines …

Gaucher disease is a lysosomal storage disease, which happens due to mutations in
GBA1/Gba1 that encodes the enzyme termed as lysosomal acid β-glucosidase. The major …

Biomarkers are useful tools to help in disease diagnosis and follow-up. According to the US
Food & Drug Administration, biomarkers are defined as measurable elements that can be …

Purpose Prognostic biomarkers help triage initial patients and inform targeted therapy
selection. Here, we explored the role of progranulin (PGRN)—implicated in processes …

In Gaucher disease, several macrophage-specific biomarkers have been validated for use in
the clinic. However, Gaucher disease is more complex involving system-wide …